E3 Journal of Environmental Research and Management

E3 Journal of Environmental Research and Management Vol. 10 (1) pp. 012-015, August 2019; © E3 Journals; ISSN 2141-7466

Neuroprotective effect of Mulberry (Morus nigra) leaf extract on acrylamide ? induced Zebrafish (Danio rerio)

Abstract

Based on previous studies, the possibility of harnessing the antioxidant potential of Morus nigra leaves to confer protection in acrylamide neurotoxicity was considered. This was studied in-vitro in acrylamide toxicity modelled Zebrafish (Danio rerio) by treatment with hydromethanolic extract of the leaf. This was supplemented by qualitative phytochemical analysis of the extract. The present study was designed to investigate the antioxidant activity of Morus nigra leaf extract using various assays. Out of these moderate increase in catalase activity, notable decrease in concentration of malondialdehyde (MDA) and a marginal increase in glutathione reductase activity was observed in zebrafish brain post treatment. This study highlights the potential of Morus nigra as a natural source of antioxidant or as an alternative drug source for the treatment of oxidative stress-related diseases such as Parkinson΄s, Alzheimer΄s, etc.

Keywords: Morus nigra, Zebrafish, Acrylamide, Oxidative stress, Antioxidants, Neurotoxicity