E3 Journal of Medical Research
E3 Journal of Medical Research Vol. 3 (3) pp. 039-041, March 2014; © E3 Journals; ISSN 2276-9900
Relation between Helicobacter pylori cagA Status and Risk of complications Peptic Ulcer in children
Sokolnyk S.V2 * , Sokolnyk S.A1 , Sorokman T.V2 , Andriychuk D.R21 Department of Pediatric Surgery, Bukovinian State Medical University (Chernivtsi, Ukraine)
2 Department of Pediatrics and Medical Genetics, Bukovinian State Medical University (Chernivtsi, Ukraine)
*Corresponding Author E-mail: Sokolnyk.Snizhana@bsmu.edu.ua
Accepted 24 February 2014
Abstract
Pathogenicity genes of Helicobacter pylori studied in children with complicated peptic ulcer disease. Found that patients with complicated ulcer disease prevails serotype I (CagA+ VacA+) Helicobacter pylori. The risk of complicated of Helicobacter-associated peptic ulcer disease increases to 8,18 times (95% CI [2,03-32,9], χ2 = 10,22, p<0,01) for the presence of Helicobacter pylori CagA gene and to 5,37 times (95% CI [5,24-18,9], χ2 = 7,44, p <0,01) in the presence of serotype I (CagA+ VacA+). Thus, CagA gene Helicobacter pylori is a factor that determines the nature of the disease in children.
Keywords: children, peptic ulcer, strains of Helicobacter pylori (CagA, VacA
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